Dendritic cells (DCs) display a considerable degree of heterogeneity. Subtypes of DCs can be identified according to their localization, phenotype, and immune function. Langerhans cells represent the DCs epidermis and express langerin/CD207 and CD1a. The class 6 semaphorin SEMA-6A defines an activation status of langerhans cells.DCs of the dermis or the lamina propria of mucosae (interstitial DCs) constitue more diverse populations characterized by the expression of DC-SIGN/CD209, CD1a (in humans only).interstitial DCs, or subsets thereof, include the macrophage mannose receptor (MMR/CD206) and the macrophage galactose lectin/asialoglycoprotein receptor (ASGPR/CD301), DCIR and FDF03. Plasmacytoid DC (pDC) also known as Interferon-procucing cells can be identified by their expression of CD303, IL-3R alpha chain (CD123) and lack of CD11c.
Shortman and Liu, 2002, Nature reviews,2, 151-. Valladeau J.,Saeland S., Seminar in Immunology,2005, 17, 273-283.  Ebner S. et al.,2004 International Immunology, 16, 877- ;Grouard G. et al.,1996, J. Exp. Med.185, 1101- Merad M., Romani N.et al.,2008 J of Investigative Dermatology,128, 251-