Antigen families

Antigen presentation

Endogenous self or pathogen-derived antigens are typically processed by DCs into peptides in a proteasome-dependent pathway. Peptides subsequently bind to MHC class I molecules (mAb DENDRITICS: DDX0250) and the complexes (mAb DENDRITICS: DDX0060) are transported to the cell surface for presentation to CD8+ alpha beta T cells. DENDRITICS has selected antibody 405H1 (mAb DENDRITICS) which recognizes the complex formed between HLA-A2 and the (58-66)-peptide of influenza virus-derived M1 matrix protein. Antibody 405H1 thus mimicks the T–cell receptor of M1/HLA-A2 specific CD8+ T cells, and is a valuable tool to quantitate processed antigen at the DC cell surface following viral infection or in models using the M1 epitope as tracer for optimizing antigen delivery.

Click on an antigen to find the related products.

  • ● HLA class I alpha 1 domain

    • DDX0250 - mAb90
      DDX0250 mAb90
      HLA class I alpha 1 domain
      Mouse IgG1

      B cell apoptosis

  • ● Influenza M1/HLA-A2 Complex

    • DDX0270 - 405H1.01
      DDX0270 405H1.01
      Influenza M1/HLA-A2 Complex
      Mouse IgG1

      Antigen presentation

  • ● Beta2-microglobulin

    • DDX0060 - mAb4
      DDX0060 mAb4
      Mouse IgM

      B cell activation